11/7/2018

Biopharma/Investing
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Earnings season is in full swing! Oh ALNY… probably a good long here…

Would readers prefer a “deep-dive” on CELG or AMGN?

Papers I’ve Read
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Will Courts Allow States to Regulate Drug Prices? Christopher Robertson, JD, PhD. NEJM 2018.
This isn’t a paper, just drivel the NEJM allowed published for some self-destructive reason. States can’t “regulate” drug prices. Countries that have ONE payor, that country’s government health body, cannot “regulate” drug prices, either. What happened when Greece couldn’t pay for Roche’s cancer drugs? Do you think Roche let Greece give them IOUs? No. They cut of supplies of life-saving medicines to a country that chose not to pay due to financial difficulty. The writer of the article seems to propose states should have the option to do the same. What this poor fellow confuses is regulation and access. Firms have a choice as to what they’ll supply at what price. If Maryland’s ill-fated attempt (reversed by Circuit Court) for drug price regulation were to somehow be found legal again, companies like mine would just stop selling to Maryland.

Maybe they can ask Greece for advice?

Clinical Trials I Noticed
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CLN-0046: Treatment of AMD Subjects with OTX-TKI. Ocular Therapeutix, Inc.
I had no idea this was a public company. Pipeline is kind of neat. OCUL is the ticker.

Vaginal Elasticity Assessment Before and After Vaginal CO2 Laser Treatment.
You got me after vaginal elasticity assessment. How do I enroll?

Briefly Reviewed: Perfect English Grammar by Grant Barrett
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Initially, I bought this small (3/4th size, 200pgs) guide for my language-impaired roommates. Of course, not being a remotely adept writer myself, I had to go through it first before recommending it to others. Barrett writes for an audience somewhere between their needs and mine. “PEG” probably should not be read by someone who hasn’t finished high school, but I found it too incomplete and scattered for a scientific or financial professional looking to improve his knowledge of English.
Despite that, unless you’re familiar with copulas, gerunds, determiners and the myriad mind-numbing derivatives of various parts of speech that come with writing for a living, this is a nice refresher for the “too busy to care”. You should care, though.

Sports
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9/10 for my last ten football selections (some were ML). I don’t have a read on the Panthers/Steelers game, but if I make a decision before gametime, I’ll try and make a quick post. Basketball will be interesting tonight. I’m going with DEN -3 and ML, DAL+9.5 and ML, CHI+10.5 and ML, SAC+8 and ML and ATL+1 in order of conviction. I’m enjoying the NBA and predictions increase the edifying feeling.

Poker
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Bummed over some bad luck. In a 1/2 unit 6-player game, I’m 3rd to act after the binds. UTG check, call of 2 to my right and with AdJh I raise to 6. All fold except our caller villian. Flop shows Jc 2d 3s. Pot has 15 in it. Villian checks, I bet 7. Villian calls. Turn card is a 7c. Pot has 29 in it. Vil checks I bet 15, Vil calls. River is a Kc. Villain checks, I bet only 10, Vil calls and turns over 8Jc. Did I play it right?

Also lost a frustrating AI hand with JJ vs AKo. My luck!

Personal
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Spoke with my attorneys today. Brafman is really a great fellow. Lawyers are generally despised, typically for good reason. Ben is not one of those. Several of my other attorneys are fantastic friends and great advisors. They all know who they are, but I have about 10 fantastic attorneys that have become friends. Hopefully it’s not just for the bills 🙂

11/5/2018

Biopharma/Investing
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So, I guess we’ll find out if the Pfizer/Glycomimetics drug for sickle cell works next year.

I still like SRPT and GBT.

Interesting to see VRTX’s early stage programs include FSGS (hey, that’s my disease!) and PKD. What’s up with that!

I think I will do a “deep-dive” for a stock, including a full DCF (done in my notebooks!). I’ll try and shoot for one stock a week. That’ll cover 52 stocks out of a universe of… 500? Not much coverage but I beg the reader’s forgiveness. Maybe I can do two some weeks.

Clinical Trials I’ve Noticed
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Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma. Drug: molibresib. GlaxoSmithKline
This BET inhibitor must be working for GSK to take this action.

Lenalidomide in Anti-MAG Neuropathy. Phase Ib Study.
I’ve never heard of Anti-MAG Neuropathy. Seems like myasthenia gravis. Might be a good indication for would-be drug company builders.

A RETROspective Study of Patients with TK2d. Drug: dC/dT. Modis Therapeutics Inc.
This Orbimed-funded orphan drug company just announced a $30m Series A. I don’t know a lot about this disease or putative drug, but interested in learning more. Someone shoot me a paper or two on this, please.

Assess the Gluten Degradation Activity of PvP001 and PvP002 in Healthy Adult Volunteers. PvP Biologics, Inc.
This Celiac Disease-focused company is fairly quiet about what they do. I wonder what these drugs are… oral enzymes perhaps? Could be a big product but I thought Takeda had rights.

BHV-4157 in Adult Subjects with Spinocerebellar Ataxia. Troriluzole. Biohaven Pharmaceuticals Inc.
I know very little about BHVN but I do know a lot about riluzole. I suspect this riluzole derivative will do nothing, but who knows.

Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy. NCI.
This is Glycomimetic’s E-selectin drug.

Pinometostat and 5-Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement. NCI.
This is Epizyme’s DOT1L drug.

Brief Review – My Inventions – The Autobiography of Nikola Tesla
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I found this tiny volume confirmatory of the recent biography: Tesla is simultaneously delusional and brilliant. He’s a man of science but also of the supernatural. Truly one of the most bizarre individuals I’ve ever read about.

I’ll try to make a book “section” of the site. If anyone is a WordPress pro perhaps my people can reach out to you to coordinate this. A simple list of books I’ve read while I’ve been in my New Jersey office might be interesting to the reader.

Sports
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The Patriots, Steelers and Chiefs came through and my small token on the Bills did not (so much for their fearsome defense). I’m 8/9 in my last few football selections. My algorithm is a fairly simple relative-strength stochastic. I think the big question is how much “decay” one builds into memory. Does a team’s performance from last year matter? Two years ago? Is there a variable one could create to model individual player performance longitudinally and another variable to assess team roster identity? Lots of ways to improve an algorithm. Lots of ways to mess it up, too 🙂

So much for the Knicks as well. I forgot to include the “never bet on the Knicks” function that all NYers have come to appreciate. The Wizards have a pretty good roster but a bad start to the season. Hard to predict those things. I also flunked on the T’Wolves game but did pick up the Raptors/Lakers. Poor Lebron. My basketball look-back period is very short, unlike football, and a few other differences exist between formulae.

Personal
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I have to refill prescriptions here, just like in the real world. Go figure. No copay.

75% of the people here shouldn’t be here. I doubt our founding fathers wanted a prison state where most individuals are incarcerated for long periods of time for owning guns and peddling “illegal drugs”. Very sad. So often, jail is an expected outcome of a troubled, urban youth. The cost of incarceration is incredible and few lessons are learned. If anything, the inmate is set back further from potential redemption.

I fear the plethora of cats that cohabitate this compound will be very cold this winter. The tough guy persona the reader has come to love is betrayed by my love for these furry interlopers. The cats are well-fed, thanks to inmate willingness to share lunch. I sometimes wonder if while lounging about they ask each other what they’re in for. “Ate the dog’s treats.” “Catnip, possession and intent to sell.” “Dogslaughter. (gasp!)”.

11/4/2018

Biopharma/Investing
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Poor PBYI. Hard to tell if its a ‘value stock’ now.

Innovent is public. $3b USD MC. Another PD1 player (and Beigene competitor).

Clinical Trials I Noticed
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Neoadjuvant and Concurrent PD-1 Blockade Combined with Definitive Chemoradiation in Nasopharyngeal Carcinoma. Innovent.
Sintilimab is Innovent (and Lilly’s) PD1 mab. See above for brief comment on innovent.

Safety, Tolerability, Pharmacokinetics, and Antitumor Study of ADCT-601 to Treat Advanced Solid Tumors. ADC Therapeutics.
An AXL armed antibody. This is in addition to their CD19, CD25, CD22, PSMA and DLK1 ADCs. This company is probably worth a few billion.

A Study of Lobaplatin/Etoposide With or Without Anlotinib Maintenance Therapy in Patients with ES-SCLC.
Well, China is here. Between anlotinib and apatanib, you have two home-grown TKIs from China. Lobaplatin is a Chinese platinum as well. China is sort of like the new Japan for pharma.

Clinical Trial Using the Proteolytic Fraction P1G10 From V. Cundinamarcensis to Heal Diabetic Foot Ulcer. Federal University of Minas Gerais.
Not for me but possibly a good opportunity for would-be in-licensors out there.

Comparison of the Efficacy & Safety of Resusix with FP24 in Patients with Acquired Coagulopathy. Entegrion, Inc.
Pretty interesting alternative to FFP.

Sports
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Nothing too exciting this weekend. I think the Patriots -5 are fairly safe against the lowly Packers. It’s painfully clear Rodgers can’t carry them this season. Also trying the Knicks+ 7 tonight. We’ll see!