Cyclin-Dependent Kinase 12, Immunity, and Prostate Cancer. Emmanuel S. Antonarakis. NEJM 379;13:1087-1089.
So CDK12 mutants are PD1-inhibitor sensitive. The bigger question is why am I reading a summary of a Cell paper in NEJM? If I wanted “basic research”, I’d read (and I do) Cell (although this work is more “translational” than “basic”, if you can figure out that meta).
Status dystonicus due to missense variant in ARX: diagnosis and management. Gorman et al. Eu J Pediatric Neurology 2018.
I’ve always followed epileptic encephalopathies. They’re tragic and have so many different causes–a good combination for a drug developer. I don’t know much about ARX–just a non-descript development protein to me–and this paper doesn’t help much. Having said that, status dystonicus is extremely rare. Sometimes found in PKAN.
Limiting State Flexibility in Drug Pricing. Bagley & Sachs. NEJM 397;11:1002-1004.
Bagley & Sachs use Exondys as a scapegoat for changing Medicaid law. This is a drug that is so rarely used it is not even close to 0.1% of drug spend. But they need to rewrite laws because of it. Is anyone else sick of this? If this was a peer-reviewed journal, it would never fly.
Had a very nice Thanksgiving here! Turkey sandwich was banging.
Poker is a little better. I have to play more aggressively. No more 2x raises (unless it is for misdirection). Tightening up a bit in the situations where I lose a lot: Ace and low kicker (9 or less). I did get crippled on one hand:
I’m dealt AKo in late position. UTG calls, I raise 3x, villain-felon calls. Flop is rainbow AK3. He bets the pot and I call. The next card is a 7. He bets the pot and I call. I figure he has A and a low kicker, maybe even two pairs. Finally a J shows on the river. Can you predict the rest? He bets I reraise, he calls and flips the Q10o. I could have just called or folded I suppose. The hand would have cost a lot less.
From Inside A Hole – A Poem
the slit opens.
the tiny portal to the world.
slices of fetid turkey are thrown through.
the cold floor greets the meal.
a cranberry sludge drips through the hole,
obscuring a gang oath since rescinded.
a surprised grunt returns my valediction
and the door slams.