A	B	C
1	Main
2		Brand	fka SAGE-217
3		Generic	zuranolone
4		MOA	GABA-A pam, synaptic and extrasynaptic receptors (handwaving?)
5		Clinical Trials
6			Phase III CORAL
7			-8.9 zur+ADT vs. 7.0 placebo+ADT at day 3
8			11.7 zur vs. -10.1 at day 15?
9			Day 42, no better than ADT
10
11			Phase III WATERFALL
12
13
14
15			Phase III "SHORELINE"
16
17
18			Phase III "MOUNTAIN" - NCT03672175 outpatient vs placebo. 30mg, 20mg, placebo
19			Day 15 HDRS-17 failed to meet PE, p=0.116
20			-12.5 vs. -11.1 for placebo, -11.5 for 20mg.