A	B	C
1	Main
2		Brand Name	Eliquis
3		Generic Name	apixaban
4		Indication	prevention of DVT in patients undergoing knee replacement surgery. VTE prevention following orthopedic surgery and prevention of stroke and systemic embolism in AF. ACS
5		Mechanism	Factor Xa inhibitor
6		Administration	Oral
7		Economics	PFE
8		Competition	warfarin, BAY-59-7939
9		Clinical Trials
10			Phase II data n=1217 - ASH 2006
11			Apixaban had 8.6% VTE+death vs 15.6% for enoxaparin and 26.6% for warfarin.
12			0%-3% major bleeding for apixaban vs 0% bleeding for control groups.
13
14			ADVANCE-1 Phase III
15
16
17			ADVANCE-2 Phase III
18
19
20			ADVANCE-3 Phase III
21
22
23			ARISTOTLE Phase III n=15,000
24
25
26
27			Phase III ACS - to start in 2007
28
29			Phase II ACS
30
31			Phase III AVERROES n=5600 vs Aspirin in Afib patients intolerant to warfarin
32			Stopped early 6/2010 due to benefit.