A	B	C
1	Main
2		Brand	Ibrance, fka PF-0332991
3		Generic	palbociclib
4		Indication	mBC
5		MOA	CDK4/6 inhibitor
6		SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
7		InChI	AHJRHEGDXFFMBM-UHFFFAOYSA-N
8		Molecule	C24H29N7O2, MW=447.5, LogP=1.8, HBD=2, HBA=8, RB=5, TPSA=103
9		Clinical Trials
10			Phase III "PALOMA-2" 1L ER+HER2- mBC combination with letrozole vs. letrozole
11			OS 53.9mo vs. 51.2mo - p=NS
12			PFS met