A	B	C
1	Main
2		Brand Name	Xeljanz, fka CP-690550
3		Generic Name	tofacitinib, fka tasocitinib
4		Indication	Rheumatoid Arthritis
5		Mechanism	JAK-3 Inhibitor. Janus kinase 3.
6		Papers	The Novel JAK-3 Inhibitor CP-690550 is a potent immunosuppressive agent in various murine models. Kudlacz et al. Am J of Transplantation 2004;4:51-57.
7		Competition	INCY
8		Economics	100% but licensed Japan to Takeda 2/3/11.
9		Clinical Trials
10			Phase IIB - ACR 2008 - 28-week data
11			Infections
12
13			EULAR 2008 update?
14			Anemia, neutropenia, liver enzyme elevation, creatinine elevations.
15			Infections